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Dr. Sirawit Ittisoponpisan

l-sirawit

 

Position: Lecturer and Researcher
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
Telephone: 095-105-0555
Address: Department of Molecular Biotechnology and Bioinformatics, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand.
Research Interest: Analysis of structural impact of genetic variants on 3D protein structures, large-scale analysis of genetic variants and mendelian diseases.

Education

PhD | Life science research | Imperial College london
         October 2014 – February 2019 (date of award: March 2019)
         Thesis title: The Relationships Between Genetic Diseases and the Structures of Protein and their Interactions
MSC | BIOINFORMATICS AND THEORETICAL SYSTEMS BIOLOGY | IMPERIAL COLLEGE LONDON (with Merit)
         October 2013 – September 2014 (date of award: November 2014)
         Dissertation title: Analysis of the Pleiotropy of Disease Phenotype Due to Amino Acid Sequence Variants
BSC | Bio and Brain Engineering | KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (Magna Cum Laude)
         August 2009 – December 2012 (date of award: February 2013)
         Graduation research title: Drug Indication Prediction Using Structural Similarity

Skills & Abilities

Bioinformatics
         Structure predictions
         Variant analysis

Programming language
         Python (highly skilled)
         C++ (highly skilled)
         Java
         Pascal
         Perl
         Matlab
         R

Website & Database Development
         HTML5
         CSS
         JavaScript
         SQL
         Django
         Bootstraps

Publications

  • Ittisoponpisan, S., Islam, S. A., Khanna , T., Alhuzimi, E., David, A. and Sternberg, M. J. E. (2019). Can predicted protein 3D-structures provide reliable insights into whether missense variants are disease-associated?. Journal of Molecular Biology.
  • David, A., Ittisoponpisan, S. and Sternberg, M. J. E. (2018). Protein structure analysis aids in the interpretation of genetic variants of uncertain clinical significance identified in the ldl receptor. Atherosclerosis Supplements, 34:e2-e3.
  • Ittisoponpisan, S. and David, A. (2018). Structural biology helps interpret variants of uncertain significance in genes causing endocrine and metabolic disorders. Journal of the Endocrine Society, 2(8), 842-854.
  • Ittisoponpisan, S., Alhuzimi, E., Sternberg, M. J. E. and David, A. (2017). Landscape of pleiotropic proteins causing human disease: structural and system biology insights. Human Mutation, 38(3), 289-296.

Conferences

  • Sternberg, M. J. E., Ittisoponpisan, S., Khanna, T., Kelley, L., Islam, S. A., Chakravarty, D., Kundrotas, P., Vakser, I. and David, A. (2019, July). How effectively can one assess the structural impact of a missense variant in both experimental and predicted protein structures?. ISMB/ECCB 2019, Basel, Switzerland.
  • Khanna, T., Ittisoponpisan, S., Alhuzimi, E., Islam, S. A., David, A. and Sternberg, M. J. E. (2018, July). Modelling the effect of a single amino-acid variant on protein structure: How successful are we without adjusting the backbone?. ISMB 2018, Chicago, United States.
  • Kelley, L., David, A., Ittisoponpisan, S., Mezulis, S., Ofoegbu, T.C., Chakravarty, D., Vakser, I., Kundrotas, P. and Sternberg, M. J. E. (2018, June). Protein structure prediction and variant analysis using Phyre and PhyreRisk. ELIXIR All Hands 2018, Berlin, Germany.
  • Ittisoponpisan, S., Alhuzimi, E., Sternberg, M. J. E. and David, A. (2016, September). Landscape of pleiotropic proteins causing human disease: structural and system biology insights. Poster session presented at ECCB 2016, The Hague, Netherlands.

Awards

Travel Fellowship Award | 2016
         15th European Conference on Computational Biology (ECCB 2016) provides travel fellowships to help students and postdocs presenting a poster or a paper to attend the conference. Part of the travel fellowships have been supported by the International Society for Computational Biology (ISCB).
Royal Thai Government Scholarship | 2013 - 2018
         The scholarship covers full tuition fees and living expenses towards MSc and PhD degrees in the UK.
Award for Outstanding Application of Formal Design Theories | 2010
         Awarded by Korea Advanced Institute of Science and Technology.
Bronze Medal from National Olympic Competition in Informatics | 2008
         Awarded by the Institute for the Promotion of Teaching Science and Technology, Thailand.

Experiences

Research Assistant | Imperial College London | Novenber 2018 - Jaurary 2019
         Two-month contracted academic position as a research assistant in protein modelling at Structural Bioinformatics Group, Imperial College London, United Kingdom.
Intern | Prince of Songkla University | August 2013 - September 2013
         One-month internship as a teaching assistant and website developer at the Department of Molecular Biotechnology and Bioinformatics, Prince of Songkla University, Thailand.